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Why Did BMS Pay $4.1B for Turning Point Therapeutics? | https://drughunters.com/3gFh3ZO

Turning Point Therapeutics ($TPTX) was recently acquired by BMS for a whopping $4.1 billion in cash. Turning Point’s most advanced molecule is repotrectinib, a potential best-in-class ROS1/TRK/ALK tyrosine kinase inhibitor in Ph. I/II studies for cancer. The molecule has shown impressive activity in the clinic, with a median duration of response of over 30 months and activity in many patients who have failed on other drugs.

What makes this molecule special? Is it better than past inhibitors, and how do we know? What else did Turning Point have in development?

This Drug Hunter Premium article explores the science behind Turning Point and repotrectinib, one of our 2021 Molecules of the Month. If you’re not already a Premium member, sign up for a free trial to see how you can save time, find ideas, and develop your team with Drug Hunter: https://drughunters.com/fb-trial

Follow us for regular updates on significant scientific developments in small molecule drug discovery.

#chemistry #drugdiscovery #pharmaceuticals #medicine

Drug Discovery Strategies to Optimize Unbound Brain Concentrations in CNS Infectious Diseases, with Dennis Koester | https://lu.ma/w1q906iz
 
We hope this upcoming talk gives you helpful tips for how to navigate the blood-brain barrier on your next project!
 
Brain-penetration plays a crucial role for compounds directed to treat CNS diseases. Dennis will present state-of-the-art knowledge of in silico, in vitro, and in vivo tools to assess, predict, and optimize brain-partitioning for CNS drugs. He’ll explain different multiparameter scores to pre-select compounds for synthesis and discuss how they perform against machine-learning models. Furthermore, he’ll share which in vitro assays should be used to decide on advancing CNS active compounds. The determination of unbound brain concentration, why it matters and how it can be optimized will be discussed. Dennis will address some common misconceptions in CNS drug discovery, and will conclude with a case study from a CNS drug discovery campaign in Human African Trypanosomiasis.
 
Dennis Koester, Ph.D. is an Associate Director in the Medicinal Chemistry Group at FibroGen in San Francisco, CA. He earned his PhD from Göttingen University with Prof. Daniel Werz working in carbohydrate chemistry. During his graduate work he pursued an interdoc at Kyoto University with Prof. Yoshiaki Nakao in cooperative catalysis. He completed two Postdocs at Münster University with Prof. Frank Glorius working on Rh catalysis, and at Stanford University with Prof. Barry Trost in enantioselective and transition metal-catalysis. Prior to his current position he worked at Novartis in Emeryville, CA as a Principal Scientist in their Global Discovery Chemistry Group. 
 
 #pharmaceuticals #drugdiscovery #medicine #chemistry

Meet the Founder and CEO of a Billion-Dollar CDMO, Oliver Ju | https://lu.ma/w1q906iz
 
Today at 7pm EST
 
Everyone in pharma relies on contract R&D to bring compounds to the clinic. But who's behind these critical enterprises, and what are their stories? 
 
In this upcoming Drug Hunter Flash Talk, we have an exclusive interview with the founder and CEO of a CDMO doing $600M in annual revenue, Porton Pharma Solutions Ltd. He'll tell us about his story, how and why he started Porton, and what he wishes people knew about the industry.
 
 #pharmaceuticals #drugdiscovery #medicine #chemistry

Molecules of the Month – October 2022 | https://drughunters.com/MoTM22Oct

Grab a coffee and check out ten of the most interesting and instructive small molecule case studies that appeared in the literature in Oct. 2022 below:

sebetralstat - an oral, on-demand plasma kallikrein (PKa) inhibitor - https://drughunters.com/3EQCpvj

GDC-2394 - an oral NLRP3 inflammasome inhibitor - https://drughunters.com/3OKb81Y

compound 5g - a selective CDK2 kinase inhibitor - https://drughunters.com/3irITc8

AZD1656 - an oral glucokinase activator - https://drughunters.com/3EM8fsU
JNJ-64264681 - a covalent Bruton’s tyrosine kinase inhibitor - https://drughunters.com/3gEyzNO

BI-0474 - a covalent KRASG12C inhibitor - https://drughunters.com/3XIpmV3

compound 57 - an oral allosteric EGFRL858R inhibitor - https://drughunters.com/3iq0XUp

AN15368 - an oral Cleavage And Polyadenylation Specificity Factor inhibitor - https://drughunters.com/3udp1MN

UCB7362 - an oral plasmepsin X inhibitor - https://drughunters.com/3OLd766

BAY-069 - a branched-chain amino acid transaminase (BCAT) 1/2 inhibitor - https://drughunters.com/3BilH79

Learn more about the molecules in the full reviews linked above which cover: why the molecules matter, how they were discovered, the key steps behind optimization, how the drugs work, why the targets were chosen, interesting toxicology and clinical data, and more.

Sign up for our free weekly newsletter here to get regular updates like this straight to your inbox: https://drughunters.com/3UKjtVp

#pharmaceuticals #drugdiscovery #medicine #chemistry

Meet the Founder and CEO of a Billion-Dollar CDMO, Oliver Ju | https://lu.ma/w1q906iz
 
December 1st, 7pm EST
 
Everyone in pharma relies on contract R&D to bring compounds to the clinic. But who's behind these critical enterprises, and what are their stories?
 
In this upcoming Drug Hunter Flash Talk, we have an exclusive interview with the founder and CEO of a CDMO doing $600M in annual revenue, Porton Pharma Solutions Ltd. He'll tell us about his story, how and why he started Porton, and what he wishes people knew about the industry.
 
 #pharmaceuticals #drugdiscovery #medicine #chemistry

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Why Did BMS Pay $4.1B for Turning Point Therapeutics?

Turning Point Therapeutics ($TPTX) was recently acquired by BMS for a whopping $4.1 billion in cash. Turning Point’s most advanced molecule is repotrectinib, a potential best-in-class ROS1/TRK/ALK tyrosine kinase inhibitor in Ph. I/II studies for cancer. The molecule has shown impressive activity in the clinic, with a median duration of response of over 30 months and activity in many patients who have failed on other drugs.

What makes this molecule special? Is it better than past inhibitors, and how do we know? What else did Turning Point have in development?

This Drug Hunter Premium article explores the science behind Turning Point and repotrectinib, one of our 2021 Molecules of the Month. If you’re not already a Premium member, sign up for a free trial at the link in our bio to see how you can save time, find ideas, and develop your team with Drug Hunter:

Follow us for regular updates on important scientific developments in small molecule drug discovery.

#PhotoDescription: repotrectinib, tyrosine kinase inhibitor, an orally available inhibitor of multiple tyrosine kinases, has been granted three breakthrough therapy designations from the FDA, acquired by BMS from Turning Point Therapeutics

#drughunter #chemistry #drugdiscovery #pharmaceuticals #STEM #science #biology

Drug Discovery Strategies to Optimize Unbound Brain Concentrations in CNS Infectious Diseases

We hope this upcoming talk gives you helpful tips for how to navigate the blood-brain barrier on your next project!
 
Brain-penetration plays a crucial role for compounds directed to treat CNS diseases. Dennis will present state-of-the-art knowledge of in silico, in vitro, and in vivo tools to assess, predict, and optimize brain-partitioning for CNS drugs. He’ll explain different multiparameter scores to pre-select compounds for synthesis and discuss how they perform against machine-learning models. Furthermore, he’ll share which in vitro assays should be used to decide on advancing CNS active compounds. The determination of unbound brain concentration, why it matters and how it can be optimized will be discussed. Dennis will address some common misconceptions in CNS drug discovery, and will conclude with a case study from a CNS drug discovery campaign in Human African Trypanosomiasis.
 
Dennis Koester, Ph.D. is an Associate Director in the Medicinal Chemistry Group at FibroGen in San Francisco, CA. He earned his PhD from Göttingen University with Prof. Daniel Werz working in carbohydrate chemistry. During his graduate work he pursued an interdoc at Kyoto University with Prof. Yoshiaki Nakao in cooperative catalysis. He completed two Postdocs at Münster University with Prof. Frank Glorius working on Rh catalysis, and at Stanford University with Prof. Barry Trost in enantioselective and transition metal-catalysis. Prior to his current position he worked at Novartis in Emeryville, CA as a Principal Scientist in their Global Discovery Chemistry Group. 
 
Read the full story at the link in our bio

#PhotoDescription: Photo of Dennis Koester Ph.D. Associate Director in Medicinal Chemistry Group at FibroGen

#drughunter #chemistry #drugdiscovery #pharmaceuticals #STEM #science #biology

Meet the Founder and CEO of a Billion-Dollar CDMO, Oliver Ju

Today at 7pm EST
 
Everyone in pharma relies on contract R&D to bring compounds to the clinic. But who's behind these critical enterprises, and what are their stories?
 
 In this upcoming Drug Hunter Flash Talk, we have an exclusive interview with the founder and CEO of a CDMO doing $600M in annual revenue, Porton Pharma Solutions Ltd. He'll tell us about his story, how and why he started Porton, and what he wishes people knew about the industry.

Sign up at the link in our bio

#PhotoDescription: Flash Talk, Meet the Founder and CEO of a Billion-Dollar CDMO, Oliver Ju, 4 pm PST, 7pm EST, December 1st, how and why he started Porton, what he wishes people knew about the industry, drug hunter + Porton

#drughunter #chemistry #drugdiscovery #pharmaceuticals #STEM #science #biology

2022October #MoleculesOfTheMonth

Ten of the most interesting and instructive small molecule case studies that appeared in the literature in Oct. 2022 appear below:

Sebetralstat - an oral, on-demand plasma kallikrein (PKa) inhibitor
GDC-2394 - an oral NLRP3 inflammasome inhibitor 
Compound 5g - a selective CDK2 kinase inhibitor 
AZD1656 - an oral glucokinase activator 
JNJ-64264681 - a covalent Bruton’s tyrosine kinase inhibitor 
BI-0474 - a covalent KRASG12C inhibitor 
Compound 57 - an oral allosteric EGFRL858R inhibitor 
AN15368 - an oral Cleavage And Polyadenylation Specificity Factor inhibitor 
UCB7362 - an oral plasmepsin X inhibitor 
BAY-069 - a branched-chain amino acid transaminase (BCAT) 1/2 inhibitor

In the premium deep dive for each molecule you’ll find its recent publication, why the molecules matter, how they were discovered, the key steps behind optimization, how the drugs work, why the targets were chosen, interesting toxicology and clinical data, and more.

Use the link in our bio to get a free trial today to check out this month's molecules and check out substructure search and more features.
 
Sign up for our free weekly newsletter in our bio to get more content like this straight to your inbox. 
 
#drughunter #chemistry #drugdiscovery #pharmaceuticals #STEM #science #immunology #biology

Meet the Founder and CEO of a Billion-Dollar CDMO, Oliver Ju

December 1st, 7pm EST
 
Everyone in pharma relies on contract R&D to bring compounds to the clinic. But who's behind these critical enterprises, and what are their stories?
 
 In this upcoming Drug Hunter Flash Talk, we have an exclusive interview with the founder and CEO of a CDMO doing $600M in annual revenue, Porton Pharma Solutions Ltd. He'll tell us about his story, how and why he started Porton, and what he wishes people knew about the industry.

Sign up at the link in our bio

#PhotoDescription: Flash Talk, Meet the Founder and CEO of a Billion-Dollar CDMO, Oliver Ju, 4 pm PST, 7pm EST, December 1st, how and why he started Porton, what he wishes people knew about the industry, drug hunter + Porton

#drughunter #chemistry #drugdiscovery #pharmaceuticals #STEM #science #biology

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The Donut Shoppe

Saman

Eating this delicious, fresh and light salad today so we can enjoy a plato navideño mañana 🥗🤤 #Saman

The best pair of (empanadas) operadas in all of Miami 🤩 #Saman

We are already on our 5th plato navideño 🤣🎄 what about you?! #Saman

This is us offering you the best meal you'll have all week 💪🏽 #Saman

Have yourself a forking delicious bite of our food today 🤤🍴 #Saman

Saman on Facebook

We're wrapping up the year ✨
Thank you for all the love and tasty experiences you shared with us in 2022!
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#newyear #newyearseve #samanarepas #venezuelanrestaurant #togo #fooddelivery #arepas #miamifood #miamieats

And how are you spending your Thursday? 
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#venezuelanfood #togo #guacamole #guac #picodegallo #churrasco #miamieats #parrilla #miamifoodscene #miamifood #delivery

Come to Saman Arepas for an end-of-the-year meal, and let it snow ❄️
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#samanarepas #arepas  #patacon #patacones #pataconesrellenos #venezuelanfood #venezuelanrestaurant #miamifood #miamieats #comidavenezolana

Sharing is caring, and your perrito certainly loves it 🐶🥩
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#churrasco #venezuelanfood #venezuelanrestaurant #samanarepas #barbecue #miamieats #miamifood #pe

Saman wishes everyone a Merry Little Christmas 🎄🎅🏼🎁
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#christmas #venezuelanrestaurant #christmasmeal #christmasdinner #platonavideno #miamifood #miami

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Saman on Twitter

Surf and Turf Saman style 🐟️🥩🤤 #Saman⁠
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Eating this delicious, fresh and light salad today so we can enjoy a plato navideño mañana 🥗🤤 #Saman ⁠
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#venezolanosenmiami #miamieats #miamifoodporn #miamifoodblogger #bestfoodmiami #foodiemiami #miamilunch #foodieseofinstagram #doralrestaurants #miamideals #foodiesmiami #miamiinstafood #brickellfoodies #soflofoodie #doralfood #seafoodmiami #instafood #foodie #foodgasm #foodstagram⁠

The best pair of (empanadas) operadas in all of Miami 🤩 #Saman⁠
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#empanadasvenezolanas #empanadasoperadas #empanadas #cocinavenezolana #venezolanosenelmundo #miamifood ⁠
#miamieats #instafood #food #foodporn #yummy #delicious ⁠
#miamilife #bestfoodmiami #foodiemiami #miamibrunch

We are already on our 5th plato navideño 🤣🎄 what about you?! #Saman⁠
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#venezuelanarepas #miamifoodscene #miamifoodie ⁠#venezolanosendoral⁠ ⁠#venezuelanrestaurant⁠ #doralfood ⁠#doralflorida #cocinavenezolana #comidavenezolana #miamicatering #yelpmiami #venezuelanfood #saborvenezolano ⁠#arepasvenezolanas #gastronomiavenezolana #miamifood #navidadvenezolana #cenanavideña #hallacas #hallacasvenezolanas #hallaca #pandejamonvenezolano #pandejamon #platonavideño #llegolanavidad #cateringmiami ⁠#ensaladadegallina #asado

This is us offering you the best meal you'll have all week 💪🏽 #Saman⁠
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#arepa #venezuelanarepas ⁠#miamirestaurants #miamifoodie #bestfoodmiami #arepas #arepalovers #arepasvenezolanas #areparellena #quesodemano #venezolanosenmiami #venezolanosendoral #doral #doralflorida #miamidinner #doralfood #arepalover #miamiculinary #foodiesmiami #brickellfoodies #foodbloggermiami #arepitas #foodiemiami⁠ #yummy #instafood #foodporn #food #tasty⁠

Saman on Instagram

Cahn's Bliss Company

Philos Care

Switch

Rhythmic Equations

Phoenix House California

Javatino

Product Design

What's better than beer on a hot day? A Javatino cold brew! #Javatino 😎💦❤️

For when you want something nice and balanced, try our house blend, it never disappoints! #Javatino

Come join us at the market tomorrow! We'd love to see you 😁
Windermere Farmer’s Market 🍎🍊🫑 9:00 am-2:00 pm #Javatino

Coffee and ice cream are a dream pairing, especially during these hot summer months! We love adding a little vanilla to ours when we want to cool down with something yummy! 🍨☕️ What ice cream do you like to add to your coffee? Let us know below 👇🏼 #Javatino #nationalicecreamday

Photo by Ross Parmly

There is nothing like watching your espresso getting made! 😍 #Javatino

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For when you want something nice and balanced, try our house blend, it never disappoints! #Javatino ⁠
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#orlandocafe #orlandorestaurant #orlandofoodscene #orlandocoffeeshops #407 #orlandolifestyleblogger #freshlyground #orlandovegans #windermerefl #orlandorestaurants #orlandoblog ⁠
#orlandofoodies #yelporlando #orlandofoodblogger #organiccoffee #fairtradecertified #fairtradecoffee ⁠
#premiumcoffee #subscriptioncoffee ⁠
#coffeegeek #coffeeculture #coffeeroasters

Come join us at the market tomorrow! We'd love to see you 😁⁠
Windermere Farmer’s Market 🍎🍊🫑 9:00 am-2:00 pm #Javatino⁠
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#orlandofoodie #orlandocoffee ⁠
#orlandocafe #orlandorestaurant #orlandofoodscene #orlandocoffeeshops #407 #orlandolifestyleblogger #freshlyground #orlandovegans #windermerefl #orlandorestaurants #orlandoblog ⁠
#orlandofoodies #yelporlando #orlandofoodblogger #organiccoffee #fairtradecertified #fairtradecoffee ⁠
#premiumcoffee #subscriptioncoffee ⁠
#coffeegeek #coffeeculture #coffeeroasters

Coffee and ice cream are a dream pairing, especially during these hot summer months! We love adding a little vanilla to ours when we want to cool down with something yummy! 🍨☕️ What ice cream do you like to add to your coffee? Let us know below 👇🏼 #Javatino #nationalicecreamday⁠
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Photo by Ross Parmly ⁠
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#orlandocafe #orlandorestaurant #orlandofoodscene #orlandocoffeeshops #407 #orlandolifestyleblogger #freshlyground #orlandovegans #windermerefl #orlandorestaurants #orlandoblog ⁠
#orlandofoodies #yelporlando #orlandofoodblogger #organiccoffee #fairtradecertified #fairtradecoffee ⁠
#premiumcoffee #subscriptioncoffee ⁠
#coffeegeek #coffeeculture #coffeeroasters

There is nothing like watching your espresso getting made! 😍 #Javatino ⁠
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#orlandofoodie #orlandocoffee ⁠
#orlandocafe #orlandorestaurant #orlandofoodscene #orlandocoffeeshops #407 #orlandolifestyleblogger #freshlyground #orlandovegans #windermerefl #orlandorestaurants #orlandoblog ⁠
#orlandofoodies #yelporlando #orlandofoodblogger #organiccoffee #fairtradecertified #fairtradecoffee ⁠
#premiumcoffee #subscriptioncoffee ⁠
#coffeegeek #coffeeculture #coffeeroasters

It's world chocolate day and we just love celebrating one of our favorite snacks! What is your favorite chocolate to eat along with your coffee? Let us know below! 🍫☕️ #WorldChocolateDay #Javatino ⁠
Photo by NordWood Themes⁠
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#orlandofoodies #yelporlando #orlandofoodblogger #organiccoffee #fairtradecertified #fairtradecoffee ⁠
#premiumcoffee #subscriptioncoffee ⁠
#coffeegeek #coffeeculture #coffeeroasters

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